The three main categories of pharmacological treatments to stop smoking would give good results, according to researchers Montrealers of the Jewish General Hospital of Montreal and the McGill University.
The three types of treatments are:
the substitutive treatments to the nicotine (eraser, tablet, stamp transdermal patch, nasal spray or inhaler); the antidepressant bupropion (Zyban ®); the Varenicline (Champix ®), an agonist of the receiving of the nicotinic acetylcholine.
The researchers analyzed the results of 69 clinical tests led by more of 32 900 smokers. For their survey, they only kept the tests to which the course of the abstention of tobacco was confirmed by biochemical tests after six months and one year.
Except in the case of the nicotine inhalers, for which he / it subsists a doubt, proved the pharmacological treatment to be more efficient than the placebo. The number of the topics that always abstained from smoking six months and one year after the beginning of the treatment was always more elevated at the participants at those treaties that of the placebo group.
A dose of will in spite of all
However, at the end of one, less 30% some topics had succeeded in crushing for good, what that means to stop smoking requires, in spite of all, a good dose of will and determination, underline the authors. The proposed pharmacological approaches are therefore efficient, but it is necessary to put his there.
They also signal that one has few data that would permit to know if one or the other of these approaches includes better odds of success. One led few comparative tests in this domain. Five of the tests analyzed compared the effects of the bupropion to those of the varenicline and, in each of the cases, the Champix proved to be nearly two times more efficient than the Zyban.
Other data indicate that the association of the stamps and the transdermal bupropion or the treatment to the only bupropion would be more efficient than the exclusive use of the transdermal stamps.
Undesirable effects
As for the potential undesirable effects of these pharmacological approaches, the researchers confess that their survey does not permit to be pronounced since the majority of the effects associated can be returned to the severance of tobacco himself. In some of the tests analyzed, more than 85% of the topics placebo groups had declared to have endured undesirable effects, they make besides notice.
Let’s recall that Health Canada emitted a setting in garde2 in June 2008 concerning the neuropsychiatric undesirable effects attributable to the Champix. According to the federal Ministry, a certain number of people (listed 226 cases) that take this medicine said to have felt agitated, depressive, to have felt the hostility or to have had disturbing ideas (for example, to think about inflicting itself / themselves of the pain or to inflict some to others).
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