The moment of the day where a treatment of chemotherapy or radiotherapy is managed can have an influence marked on the therapeutic efficiency of intervention, as well as on the size of the undesirable effects.
Of the researchers of almost everywhere in the world are interested more and more to her, a branch of pharmacology that takes in account the patient’s rhythms circadian (cycles veiled/Somme, jour/Inuit, active/repots). More specifically, the aromatherapies tries to determine to what moment of the day a specific treatment could have an optimal efficiency while minimizing his/her/its potential undesirable effects. Although her " chronoptimisation" of the treatments medical anticancer is not a new concept, she/it is besides some on the agenda since some months.
Chemotherapy: during the night or the afternoon
The chemotherapy aims the destruction of the cancerous cells that has a propensity to divide and to increase quickly. He/it arrives however that the medicine managed in this goal touches healthy cells, especially if these last are in an active cycle of normal cellular division. The goal of the aromatherapies is to determine the moments where the healthy cells are to rest in order to optimize the action of the medicine that will touch the cancerous cells then that, them, don’t have a rest to deliver itself/themselves to a wild division process.
The works of the cheroot French Francis, of the university of Paris-South 11, and of his/her/its indicate that, in several cases, the discriminating choice as soon as one manages the chemotherapy can divide by five the undesirable effects and can double the sought-after therapeutic effect (resorting of the tumor). One could demonstrate thus that, following the managed medicine, the optimal moment of the treatment could be located between 1 has and 4 has of the morning or 13 has and 16 has of the afternoon.
According to the Dr David Orrell, of which the business British Physicist finalized a software permitting to foresee the pharmacological effects of a medicine according to the rhythms circadiens3, the biologic cycles can vary from a person to the other. It can be therefore necessary to conduct tests at every patient in order to be able to choose timetables of treatment personalized according to the rhythms circadian.
Radiotherapy: less pain the morning
The Canadian researcher Georg Bjarnason, of the university of Toronto, is himself for his/her/its part leaned on the problem of jocosities, a very painful undesirable effect caused by the therapies to basis of strong doses of radiation against the cancer of the neck and the head. On the 206 patients examined in the setting of sound, only 43% of people treated the morning endured a serious jocosity, against 67% of the individuals treated at the end of afternoon. On the other hand, the inflammation progressed less quickly and with less virulence at people radiated in morning.
Among the smokers (the cigarette is an aggravating factor of the undesirable effects associated to the radiotherapy), the researcher found 33% of case of jocosity in less among the patients treated the morning. Besides, the loss of weight associated to the treatment was dammed up more quickly among these subjects when one compared them to those that had been treated at the end of afternoon.
Although research present door mainly on the treatments anticancer, the experts estimate that will be able to apply it possibly to the treatment of numerous other illnesses, notably the rheumatoid arthritis, the illness of Alzheimer or the cardiovascular unrests.
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